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Simplicity in solutions

WELLNESS

Discover the wonders of HyaSphereX
Discover the wonders of HyaSphereX, where we transform the linear chain of hyaluronic acid into a soft, spherical, 3D nanogel.
This revolutionary form offers superior benefits compared to conventional hyaluronic acid, with the remarkable ability to encapsulate and enhance the absorption of active ingredients deep into the epidermis and intracellular layers.
Alternatively, you can use HyaSphereX as an active ingredient to enjoy the benefits of moisturizing, whitening, wound healing, soothing, and an effective anti-wrinkle effect.
Unlocking Skincare Wonders with HyaSphereX!

7 functions
in
1 ingredient

01

Delivery System

Enhance the efficacy with automatically encapsulate, easy, single step, low setup cost

02

Moisturizing

Hydrate the skin, prevent water loss better than hyaluronic acid

03

Soothing

Calm irritate and sensitive skin by reducing COX-2 inflammatory marker

04

Whitening

Reduce number of melanocyte

05

Anti-wrinkle

Reduce wrinkle by inhibit collagenase enzyme, anti-oxidant, prevent cell damage from UV-A exposure.

06

Wound healing

Accelerate wound closure

07

Increase stability

Prevent degradation and color change of vitamin, protein, herbal extracts

How does it work

HyaSphereX, where innovation meets transformation. We’re dedicated to elevating the efficacy and stability of bioactive molecules through a multifaceted approach.
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HyaSphereX facilitates increased cellular uptake of bioactive molecules, ensuring a more efficient and effective interaction with cells. This mechanism enhances the bioavailability of the compounds, amplifying their positive effects within the biological system.

HyaSphereX employs a proprietary mechanism to significantly increase the solubility of bioactive molecules. This breakthrough ensures that these compounds dissolve more readily, paving the way for improved formulations and enhanced therapeutic outcomes.

Our technology goes beyond conventional methods by enhancing the penetration capabilities of bioactive molecules. This means that these compounds can reach their target sites more efficiently, maximizing their impact and potential benefits.

HyaSphereX deposits and hydrates epidermis using hydrophobic part that is available on the particle’s surface as a flexible anchor and extremely hydrophilic hyaluronic acid backbone as super-humectant, respectively.

Through the moisturized skin, the very hygroelastic particle of HyaSphereX could squeeze itself with the help of moisture in the extracellular matrix (ECM).

In viable skin layers, underneath stratum corneum, HyaSphereX could be uptaken by keratinocytes and fibroblast derived cells through transcellular and paracellular transportation.

Unique hydrophobic part within swollen HyaSphereX induces the expansion of the very porous particles of HyaSphereX in the deeper skin temperature making hydration even more effective as it excels the accessibility of hydrogen bonds between water and hyaluronic acid backbone.

Both water-soluble and oil-soluble active ingredients can be bonded (non-covalent) with hydrophilic/hydrophobic part of HyaSphereX, possibly hydroxyl groups for hydrophilic polymer/ hydrophobic interaction with hydrophobic crosslink sites. So the degradation is hindered.

Inside the particle is gel matrix meaning that the viscosity is high and molecular motion of water is limited. So it slower the degradation of any molecules.

Enhanced Solubility

HyaSphereX employs a proprietary mechanism to significantly increase the solubility of bioactive molecules. This breakthrough ensures that these compounds dissolve more readily, paving the way for improved formulations and enhanced therapeutic outcomes.

Increase Penetration

Our technology goes beyond conventional methods by enhancing the penetration capabilities of bioactive molecules. This means that these compounds can reach their target sites more efficiently, maximizing their impact and potential benefits.

Optimize Cellular Uptake

HyaSphereX facilitates increased cellular uptake of bioactive molecules, ensuring a more efficient and effective interaction with cells. This mechanism enhances the bioavailability of the compounds, amplifying their positive effects within the biological system.

Hydration

HyaSphereX deposits and hydrates epidermis using hydrophobic part that is available on the particle’s surface as a flexible anchor and extremely hydrophilic hyaluronic acid backbone as super-humectant, respectively.

Passive Penetration

Through the moisturized skin, the very hygroelastic particle of HyaSphereX could squeeze itself with the help of moisture in the extracellular matrix (ECM).

Active Cellular Uptake

In viable skin layers, underneath stratum corneum, HyaSphereX could be uptaken by keratinocytes and fibroblast derived cells through transcellular and paracellular transportation.

Hyper-moisturization

Unique hydrophobic part within swollen HyaSphereX induces the expansion of the very porous particles of HyaSphereX in the deeper skin temperature making hydration even more effective as it excels the accessibility of hydrogen bonds between water and hyaluronic acid backbone.

NON-COVALENT INTERACTION

Both water-soluble and oil-soluble active ingredients can be bonded (non-covalent) with hydrophilic/hydrophobic part of HyaSphereX, possibly hydroxyl groups for hydrophilic polymer/ hydrophobic interaction with hydrophobic crosslink sites. So the degradation is hindered.

MINIMIZING THE MOLECULAR MOTION BY SPHERICAL GEL MATRIX

Insdie the particle is gel matrix meaning that the viscosity is high and molecular motion of water is limited. So it slower the degradation of any molecules.

Enhance Penetration of Bioactive

HyaSphereX enhances penetration of both water-soluble and oil-soluble active ingredients through transcellular, intercellular, and follicular route.

Prevent Degradation of Bioactive

HyaSphereX, through its unique, flexible 3D nanogel structure, help increase stability of active ingredients and the formulations.

A Glimpse of Amazing Results

HyaSphereX as a Delivery System

 

Retinol stability was tested in HyaSphereX™ solutions over 7 days at room temperature. Results show that 2-5% w/w of HyaSphereX™ increased stability 1.2-2.5 times compared to a water solution, indicating HyaSphereX™ enhances retinol stability.

To explore HyaSphereX™ solution’s impact on vitamin A-induced inflammation in keratinocytes, cells were pre-treated with HyaSphereX™-Vit A before UVA exposure. Vitamin A notably increased COX-2 expression by 64% compared to UVA alone. However, the addition of 2% HyaSphereX™ solution with vitamin A reduced COX-2 levels post-UVA exposure, indicating potential anti-inflammatory effects.

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Nine healthy volunteers applied samples twice daily for 14 days. Results showed 2% Stabilized vitamin C with 1% HyaSphereX™ reduced melanin index 1.3 times more than 2% Stabilized vitamin C alone. Clinical data suggests HyaSphereX™ enhances the whitening effects of vitamin C in skincare products.

ECOCERT COSMOS Approved

HYN Technology Delivery System

International patented

Vegan

Microplastic free

Halal

Preservative free

95% Natural origin ISO 16128

Biodegradable

China CosIng

Discover the wonders

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Technical Data Sheet

Safety Data Sheet

Application Case Studies of HyaSphereX

HyaSphereX Two-Pager

Declaration of Natural Origin

Formulation guide

experience the future of bioactive excellence.

Awards

NIA award

The winner of the National Innovation Award 2023. HYN Technology inside HyaSphereX is crowned for its foremost innovation, significantly impacting and driving economic growth.

Tech Planter TH

The winner of the National Innovation Award 2023. HYN Technology inside HyaSphereX is crowned for its foremost innovation, significantly impacting and driving economic growth.

Rohto

The winner of the National Innovation Award 2023. HYN Technology inside HyaSphereX is crowned for its foremost innovation, significantly impacting and driving economic growth.

Glico

The winner of the National Innovation Award 2023. HYN Technology inside HyaSphereX is crowned for its foremost innovation, significantly impacting and driving economic growth.

Innovation Zone Best Ingredient Award

The winner of the National Innovation Award 2023. HYN Technology inside HyaSphereX is crowned for its foremost innovation, significantly impacting and driving economic growth.

NIA award

The winner of the National Innovation Award 2023. HYN Technology inside HyaSphereX is crowned for its foremost innovation, significantly impacting and driving economic growth.

Trusted by

Mizumi Advance Nio-TXB3 Concentrate Serum

we'd love to understand your needs and curiosity, no boring sales pitch!

experience the future of bioactive excellence.